One challenge of starting a large Sass project is determining how to divide styles into partials. What should go into each partial? How is the folder structure going to be set up? How are the partials going to be imported?
When working in a team it is incredibly important that other team members can not only find the styles they are looking for, but also understand where they should add new styles. A well designed file structure, and an adherence to OO(S)CSS will help create a project that is easy to manage and maintain.